Virology USMLE Step 1 Practice Question
A 32-year-old pregnant woman at 8 weeks gestation presents with fever (38.9°C), maculopapular rash on face and trunk, arthralgias, and cervical lymphadenopathy. Vital signs show HR 98/min, RR 16/min, BP 118/76 mmHg. Laboratory testing reveals positive IgM antibodies to rubella virus and normal platelet count. She denies recent vaccination. Which of the following fetal complications is she at greatest risk for given her first-trimester infection?
Answer choices
- ACongenital cataracts, cardiac defects, and sensorineural hearing lossCorrect answer
- BLimb hypoplasia and cardiac anomalies
- CChorioretinitis and thrombocytopenia
- DHydrocephalus and periventricular leukomalacia
- EMicrocephaly and intracranial calcifications
- FCleft palate, microphthalmia, and patent ductus arteriosus
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