Virology USMLE Step 1 Practice Question
A 32-year-old man presents with fever (38.5°C), fatigue, and generalized lymphadenopathy. CD4+ count is 450 cells/μL with detectable viral load of 85,000 copies/mL. He denies opportunistic infections. A researcher studying his viral isolate notes it carries reverse transcriptase and integrates a DNA copy into host chromosomal DNA. Which enzyme is required after reverse transcription for stable viral persistence within his infected cells?
Answer choices
- AProtease inhibitor from the host
- BRNA dependent RNA polymerase
- CDNA dependent RNA polymerase
- DNeuraminidase
- EIntegraseCorrect answer
- FTopoisomerase II
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