Vascular Disease USMLE Step 1 Practice Question
A 54-year-old man with hypertension presents with hemoptysis, malaise, and dark urine over two weeks. Vital signs show BP 158/92 mmHg, HR 98 bpm, RR 20/min, Temp 37.2°C, SpO2 98% on room air. Serum creatinine is 2.8 mg/dL. Chest X-ray reveals pulmonary infiltrates. Kidney biopsy demonstrates necrotizing vasculitis of small vessels without granulomatous inflammation. Serology is positive for p-ANCA. He denies respiratory infections. Which diagnosis best explains these findings?
Answer choices
- AMicroscopic polyangiitisCorrect answer
- BBuerger disease
- CTakayasu arteritis
- DPolyarteritis nodosa
- EGranulomatosis with polyangiitis
- FGoodpasture syndrome with anti-GBM antibodies
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