Neoplasia USMLE Step 1 Practice Question
A 67-year-old man with a 40 pack-year smoking history presents with progressive weight loss, painless jaundice, and dark urine for 3 weeks. Vital signs show BP 138/82, HR 92, RR 16, temperature 37.2°C, and SpO2 98% on room air. Physical examination reveals a palpable, nontender gallbladder and no hepatomegaly. Laboratory studies show elevated conjugated bilirubin at 8.2 mg/dL and alkaline phosphatase at 156 U/L. Which of the following is the most likely diagnosis?
Answer choices
- AAcute cholangitis
- BGilbert syndrome
- CAdenocarcinoma of the head of the pancreasCorrect answer
- DGallstone pancreatitis
- EPrimary biliary cholangitis
- FHepatocellular carcinoma with biliary obstruction
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