Neoplasia USMLE Step 1 Practice Question
A 63 year old man undergoes colonoscopy after a positive stool DNA screening test. A 2.5 cm pedunculated adenoma is removed from the sigmoid colon. Molecular analysis of the adenoma demonstrates a mutation that promotes constitutive signaling through a GTP binding protein and drives progression from early to intermediate adenoma. Which gene is most likely mutated?
Answer choices
- ARET
- BWT1
- CAPC
- DKRASCorrect answer
- ERB
- FBRAF
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