Movement Disorders USMLE Step 1 Practice Question
A 32-year-old man presents with progressive cognitive decline, myoclonic jerks, and visual disturbances over 6 months. Vital signs: BP 128/82, HR 88, RR 16, Temp 37.2°C, SpO2 98% on room air. He denies recent travel or animal exposure. MRI brain shows characteristic gray matter spongiform changes. Serum 14-3-3 protein is elevated. EEG demonstrates periodic sharp wave complexes at 1-2 Hz. Which of the following is the most likely diagnosis?
Answer choices
- AAlzheimer disease
- BMitochondrial encephalomyopathy
- CViral encephalitis
- DCreutzfeldt-Jakob diseaseCorrect answer
- EEpilepsy with myoclonic seizures
- FLewy body dementia
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