Molecular Biology/Genetics USMLE Step 1 Practice Question
A 2-year-old boy presents to the emergency department with gross hematuria and a palpable right abdominal mass. Vital signs reveal blood pressure of 128/82 mmHg (>95th percentile for age). Imaging confirms a large right renal tumor. Pathology shows a heterogeneous mass containing primitive mesenchymal elements including smooth muscle, striated muscle, bone, cartilage, adipose tissue, and areas of hemorrhagic necrosis. Which of the following chromosomal locations harbors the gene responsible for this condition?
Answer choices
- AChromosome 5 (APC gene)
- BChromosome 9 (CDKN2A gene)
- CChromosome 11 (WT1 gene)Correct answer
- DChromosome 13 (RB1 gene)
- EChromosome 17 (TP53 gene)
- FChromosome 22 (NF2 gene)
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