Transcription & Translation MCAT Practice Question
A geneticist studies a patient with a mutation in the TATA-binding protein (TBP), a core component of the general transcription factor TFIID in eukaryotes. The mutation reduces TBP's affinity for the TATA box by 50-fold. What is the most likely effect on transcription of protein-coding genes?
Answer choices
- AIncreased transcription due to reduced inhibitory effect of chromatin
- BEnhanced splicing and increased protein synthesis
- CSelective activation of genes lacking TATA boxes
- DSeverely reduced or absent transcription of TATA-containing promotersCorrect answer
- EImproved binding of TFIIA and recruitment of RNA polymerase II
- FCompensatory upregulation of alternative sigma factors to maintain basal transcription
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