Enzyme Kinetics MCAT Practice Question
A pharmaceutical company develops a new inhibitor of HMG-CoA reductase for cholesterol management. Kinetic analysis shows that when the inhibitor is present, the apparent Km increases from 2 µM to 8 µM, while Vmax remains unchanged at 100 nmol/min/mg. In a Lineweaver-Burk plot, this inhibitor produces lines that intersect on the y-axis. Which type of inhibition does this inhibitor exhibit?
Answer choices
- ANoncompetitive inhibition
- BUncompetitive inhibition
- CCompetitive inhibitionCorrect answer
- DIrreversible inhibition
- EAllosteric inhibition
- FMixed-type inhibition
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