Immunology USMLE Step 1 Practice Question
A 26-year-old man presents with hemoptysis and dark urine over 5 days. Vital signs show BP 148/92 mmHg, HR 102 bpm, RR 22/min, temp 37.2°C, SpO2 94% on room air. Mild respiratory distress is noted on examination. Serum creatinine is 2.8 mg/dL (baseline 0.9). Urinalysis shows blood and proteinuria. Renal biopsy demonstrates linear IgG deposition along the glomerular basement membrane. He denies recent infections or medication changes. Which type of hypersensitivity reaction best explains these findings?
Answer choices
- AType IV
- BType I
- CType IICorrect answer
- DType III
- EImmune deficiency rather than hypersensitivity
- FType II with concurrent Type III immune complex deposition
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