Immunology USMLE Step 1 Practice Question
A 3-month-old boy presents with severe watery diarrhea, diffuse dermatitis, and poor feeding for 2 weeks. Vital signs show HR 128/min, RR 32/min, temperature 37.2°C, and BP 85/50 mmHg. He has early-onset insulin-dependent diabetes mellitus. Laboratory studies reveal absolute eosinophilia of 2,500/μL, elevated IgE levels, and normal thyroid function. Which of the following transcription factors is most likely defective?
Answer choices
- ANF kappa B
- BFOXP3Correct answer
- CGATA3
- DAIRE
- ESTAT1
- FSTAT3
See the full explanation
Get the correct-answer rationale, why each distractor is wrong, the underlying mechanism, and high-yield associations — plus adaptive practice that targets your weak areas — with a free MedBoardPRO account.