Immunology USMLE Step 1 Practice Question
A 24-year-old female with a history of allergic rhinitis is involved in an automobile accident and sustains a splenic laceration. She undergoes abdominal surgery and is then transfused with 4 units of blood of the appropriate ABO and Rh type. As the transfusion progresses, she becomes rapidly hypotensive and develops airway edema, consistent with anaphylaxis. Which of the following pre-existing conditions best accounts for these symptoms?
Answer choices
- ADiGeorge syndrome
- BWiskott-Aldrich syndrome
- CC1 esterase inhibitor deficiency
- DSelective IgA deficiencyCorrect answer
- EAIDS
- FHereditary angioedema due to C1 esterase inhibitor dysfunction
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