Immunology USMLE Step 1 Practice Question
A 28-year-old man presents with recurrent infections of the lungs, liver, and bones, along with excessive inflammation manifesting as granulomas, gingivitis, aphthous ulcers, and seborrheic dermatitis. Vital signs show BP 118/76, HR 94, RR 18, temp 37.2°C, SpO2 98%. Laboratory studies reveal elevated inflammatory markers (ESR 42 mm/hr) and normal immunoglobulin levels. Chest X-ray shows granulomatous infiltrates. He denies recent antibiotic use. This patient most likely has a deficiency of an enzyme involved in which of the following processes?
Answer choices
- APeroxisomal fatty acid oxidation
- BNucleotide salvage
- CErythrocyte oxidative protection
- DEnterocyte copper transport
- ENeutrophil oxidative burstCorrect answer
- FMacrophage apoptosis
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