Inflammatory Bowel Disease USMLE Step 1 Practice Question
A 24-year-old woman presents with a 3-month history of chronic diarrhea, bloating, and fatigue. She reports a pruritic blistering rash on extensor surfaces of her elbows. Vital signs: BP 118/76, HR 88, RR 16, Temp 37.2°C, SpO2 98%. Laboratory studies reveal hemoglobin 9.8 g/dL with iron deficiency anemia; tissue transglutaminase (tTG) IgA elevated. Small-bowel biopsy shows villous atrophy, crypt hyperplasia, and increased intraepithelial lymphocytes. Abdominal pain is absent. Which antibody is most likely positive?
Answer choices
- AAnti-mitochondrial antibody
- BIgA anti-tissue transglutaminaseCorrect answer
- CAnti-smooth muscle antibody
- DASCA
- Ep-ANCA
- FIgG anti-endomysial antibody
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