GERD and Peptic Ulcer Disease USMLE Step 1 Practice Question
A 52-year-old man presents with a 3-month history of burning epigastric pain that worsens 2-3 hours after meals and improves with antacids. He denies dysphagia or weight loss. Endoscopy reveals a 1.5-cm ulcer in the gastric antrum. Testing for H. pylori is negative. Which of the following is the most likely cause of this ulcer?
Answer choices
- AChronic nonsteroidal anti-inflammatory drug useCorrect answer
- BCrohn disease
- CGastric adenocarcinoma
- DZollinger-Ellison syndrome
- EHelicobacter pylori infection
- FAspirin sensitivity with reactive gastric mucosal inflammation
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