GERD and Peptic Ulcer Disease USMLE Step 1 Practice Question
A 45-year-old man presents with recurrent peptic ulcers and chronic diarrhea unresponsive to omeprazole 40 mg daily for 3 months. Vital signs show BP 128/82, HR 92, RR 16, temp 37.2°C, SpO2 98%. Fasting serum gastrin is 890 pg/mL (normal <100). Upper endoscopy reveals multiple ulcers in the duodenum and jejunum. Helicobacter pylori testing is negative. Which of the following is the most likely diagnosis?
Answer choices
- AZollinger-Ellison syndrome due to gastrinomaCorrect answer
- BCarcinoid syndrome
- CPernicious anemia
- DGlucagonoma
- EVIPoma
- FSevere gastroesophageal reflux disease with peptic ulcer disease
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