GERD and Peptic Ulcer Disease USMLE Step 1 Practice Question
A 52-year-old man presents with 8 years of burning substernal chest pain that worsens after large meals and when lying flat. He has chronic nocturnal cough and occasional sour taste in his mouth. He is obese and smokes 1 pack per day. Endoscopy shows salmon-colored mucosa extending upward from the gastroesophageal junction. Biopsy demonstrates intestinal-type columnar epithelium with goblet cells. Which of the following is the most likely consequence of this patient's condition?
Answer choices
- AEsophageal webs associated with iron deficiency
- BSquamous cell carcinoma of the upper esophagus
- CEsophageal rupture after retching
- DFailure of lower esophageal sphincter relaxation
- EEsophageal adenocarcinomaCorrect answer
- FHigh-grade dysplasia in Barrett esophagus
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