GERD and Peptic Ulcer Disease USMLE Step 1 Practice Question

A 61-year-old woman with severe osteoarthritis requires chronic NSAID therapy. She previously developed a gastric ulcer while taking naproxen and now presents with epigastric pain. Vital signs: BP 128/82, HR 88, RR 16, Temp 37°C, SpO2 98%. Upper endoscopy reveals a 1.5-cm antral ulcer with elevated gastrin level at 85 pg/mL. She denies current NSAID use. Which medication reduces recurrent NSAID-induced ulcer risk by increasing mucus production and decreasing acid secretion?