GERD and Peptic Ulcer Disease USMLE Step 1 Practice Question
A 64-year-old male with 40 pack-year smoking history and daily alcohol use presents with progressive dysphagia and 8-kg weight loss over 3 months. Vital signs: BP 128/82, HR 92, RR 18, Temp 37.2°C, SpO2 98%. Upper endoscopy reveals an ulcerated mass at 25 cm from incisors with shouldering at margins. Biopsy shows malignant cells. He denies reflux symptoms or antacid use. Which diagnosis best explains these findings?
Answer choices
- AEsophageal squamous cell carcinomaCorrect answer
- BAchalasia
- CEsophageal adenocarcinoma
- DBarrett esophagus
- EEsophageal leiomyoma
- FEsophageal small cell carcinoma
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