Demyelinating Diseases USMLE Step 1 Practice Question
A 45-year-old woman presents with progressive ascending paresthesias and weakness in both legs and hands over 6 weeks. Vital signs: BP 138/82, HR 94, RR 18, temp 37.2°C, SpO2 98% on room air. Nerve conduction studies reveal slowed velocities and prolonged latencies bilaterally. CSF analysis shows protein 185 mg/dL with normal glucose and cell count. She denies recent infections or medication changes. Which diagnosis best explains these findings?
Answer choices
- AChronic inflammatory demyelinating polyneuropathyCorrect answer
- BAmyotrophic lateral sclerosis
- CMultiple sclerosis
- DGuillain-Barré syndrome
- EDiabetic polyneuropathy
- FAnti-MAG neuropathy from IgM monoclonal gammopathy
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