Demyelinating Diseases USMLE Step 1 Practice Question
A 52-year-old woman with no prior neurologic history develops asymmetric vision loss, vertigo, and sensory loss in the lower extremities. Laboratory testing shows elevated inflammatory markers and positive aquaporin-4 IgG antibodies. Brain MRI reveals lesions in the optic nerves, brainstem, and spinal cord. Which of the following is the most likely diagnosis?
Answer choices
- AChronic inflammatory demyelinating polyneuropathy
- BNeuromyelitis optica spectrum disorderCorrect answer
- CSarcoidosis
- DLeber hereditary optic neuropathy
- EMultiple sclerosis
- FAquaporin-4 seronegative optic neuritis
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