COPD USMLE Step 1 Practice Question
A 46-year-old woman presents with chronic sinusitis, recurrent otitis media, and hemoptysis. She reports progressive dyspnea and denies tobacco use. Vital signs: BP 148/92, HR 102, RR 22, SpO2 91% on room air. Laboratory studies show serum creatinine 2.8 mg/dL (baseline 0.9) and positive c-ANCA with anti-PR3 antibodies. CT chest demonstrates multiple cavitary nodules with surrounding infiltrates. Urinalysis shows hematuria without proteinuria. Which diagnosis best explains these findings?
Answer choices
- AGoodpasture syndrome
- BSarcoidosis
- CGranulomatosis with polyangiitisCorrect answer
- DEosinophilic granulomatosis with polyangiitis
- EMicroscopic polyangiitis
- FChronic obstructive pulmonary disease with secondary infection
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