Congenital Heart Disease USMLE Step 1 Practice Question
A 3-week-old female infant born to a mother with rubella infection during the first trimester presents with fever (38.2°C), tachycardia (160 bpm), tachypnea (52 breaths/min), and SpO2 98% on room air. Physical examination reveals a continuous machinery murmur, cataracts, sensorineural hearing loss, and hepatosplenomegaly (liver 4 cm below costal margin). Laboratory studies show elevated transaminases. She has not received any cardiac medications. Which cardiac lesion is most commonly associated with congenital rubella syndrome?
Answer choices
- AVentricular septal defect
- BTransposition of the great arteries
- CTetralogy of Fallot
- DPatent ductus arteriosusCorrect answer
- EAtrial septal defect
- FPulmonary stenosis with intact ventricular septum
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