Cardiovascular Drugs USMLE Step 1 Practice Question
A 59-year-old man with hypertension and diabetic kidney disease is started on lisinopril 10 mg daily. One month later, his blood pressure is 128/82 mmHg (improved from 158/96), heart rate 72/min, and he reports a persistent dry cough without dyspnea. Serum creatinine is 1.8 mg/dL (baseline 1.6), and chest X-ray shows no infiltrates. He denies recent upper respiratory infection. Which of the following best explains this adverse effect?
Answer choices
- AExcess aldosterone secretion
- BReflex sympathetic activation from venodilation
- CAccumulation of bradykininCorrect answer
- DInhibition of sodium chloride cotransport in the distal tubule
- EDirect beta 1 receptor blockade
- FAccumulation of substance P from reduced ACE-mediated degradation
See the full explanation
Get the correct-answer rationale, why each distractor is wrong, the underlying mechanism, and high-yield associations — plus adaptive practice that targets your weak areas — with a free MedBoardPRO account.