Biostatistics & Study Design USMLE Step 1 Practice Question
A 68-year-old man presents with fatigue, dyspnea, and petechiae. Vital signs show HR 102 bpm, BP 128/76 mmHg, RR 18/min, and SpO2 94% on room air. CBC reveals WBC 45,000/μL with 60% blasts; hemoglobin 7.2 g/dL. A genomic study analyzes 10,000 gene expression differences in his leukemic cells to identify prognostic markers. No hepatosplenomegaly is noted. The researchers want to limit the expected proportion of statistically significant results that are false positives. Which approach is most directly aimed at this goal?
Answer choices
- ARemove outliers after analysis
- BMatch cases and controls
- CIncrease the sample size
- DControl the false discovery rateCorrect answer
- EUse a one tailed test
- FControl the familywise error rate
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