Biostatistics & Study Design USMLE Step 1 Practice Question
A residency program introduces a sepsis checklist intervention across 10 hospitals, with each site randomly assigned a staggered implementation month over 12 months. Baseline sepsis mortality rates averaged 18-22% across sites. Outcomes including 30-day mortality, lactate clearance within 6 hours, and time-to-antibiotics are measured continuously before and after implementation at each hospital. No concurrent interventions were introduced. Which trial design is being used?
Answer choices
- AFactorial trial
- BCross over trial
- CStepped wedge trialCorrect answer
- DCase control study
- ECluster randomized parallel trial
- FInterrupted time series
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