Biostatistics & Study Design USMLE Step 1 Practice Question
A 59 year old man with refractory lymphoma enrolls in a phase 2 trial with 3 treatment arms. After a planned interim analysis, the arm with the lowest response rate is dropped and subsequent participants are randomized only among the remaining arms according to the prespecified protocol. Which design feature does this best illustrate?
Answer choices
- AAdaptive trial designCorrect answer
- BCrossover trial
- CAllocation concealment
- DBlock randomization
- ECase cohort sampling
- FSequential analysis with fixed stopping rules
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