Biostatistics & Study Design USMLE Step 1 Practice Question
A 52-year-old woman with rheumatoid arthritis (ESR 48 mm/h, CRP 12 mg/L) presenting with joint pain and morning stiffness is screened for a biologic therapy trial. She has no history of cardiac disease or diabetes. Patients with major comorbidities are excluded, medication adherence is monitored electronically, and outcomes are assessed at frequent protocolized visits by dedicated research staff. Which trial type is most consistent with this design?
Answer choices
- AExplanatory efficacy trialCorrect answer
- BCase series
- CPragmatic trial
- DStepped wedge trial
- ECross sectional study
- FObservational cohort study
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