Beta Blockers USMLE Step 1 Practice Question
A 59-year-old man with coronary artery disease and hypertension (BP 145/92 mmHg, HR 68) starts high-intensity lipid-lowering therapy. Three months later, he reports proximal muscle soreness and fatigue. Laboratory testing reveals elevated creatine kinase (892 U/L) and normal renal function. He denies dark urine and takes metoprolol for cardiac protection. Which of the following best describes the primary mechanism of the most likely offending drug causing his myopathy?
Answer choices
- ABinding of bile acids in the intestinal lumen
- BInhibition of intestinal cholesterol absorption
- CInhibition of lipoprotein lipase
- DInhibition of HMG CoA reductaseCorrect answer
- EActivation of PPAR alpha
- FInhibition of the sarcoplasmic reticulum calcium-ATPase pump
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