Beta Blockers USMLE Step 1 Practice Question
A 57-year-old woman with type 2 diabetes and hypertension is started on lisinopril 10 mg daily. Two weeks later, she presents with a persistent dry cough, dyspnea, and wheezing. Vital signs show BP 128/76 mmHg, HR 82, RR 22, temperature 37.2°C, and SpO2 98% on room air. Chest X-ray reveals no infiltrates or pulmonary edema. She denies fever, sputum production, or recent upper respiratory infection. Which mechanism best explains this adverse effect?
Answer choices
- AIncreased aldosterone secretion
- BEnhanced prostaglandin degradation
- CDirect beta 2 receptor stimulation
- DAccumulation of bradykininCorrect answer
- EBlockade of sodium channels in airway nerves
- FInhibition of angiotensin II type 2 receptor signaling
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