Behavioral Science & Ethics USMLE Step 1 Practice Question
A 55-year-old woman with metastatic ovarian cancer asks her oncologist about a phase I clinical trial for a new chemotherapy agent. The oncologist explains that phase I trials primarily assess safety and dosing in humans. The patient asks what her chance of tumor response is. Which of the following is the most accurate response?
Answer choices
- APhase I trials are designed to maximize tumor response
- BPhase I trials guarantee at least a partial response in most participants
- CTumor response data are not collected during phase I trials
- DPhase I trials have response rates comparable to standard chemotherapy
- EPhase I trials typically show a tumor response rate of less than 5%Correct answer
- FPhase I trials typically demonstrate tumor response rates between 20-40% based on historical precedent
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