Bacteriology USMLE Step 1 Practice Question
A 32-year-old woman presents to the emergency department with a 2-day history of fever, severe headache, and neck stiffness. She also reports photophobia and mild confusion. Temperature is 39.2°C, heart rate 102 bpm, blood pressure 118/76 mmHg, respiratory rate 18/min, and oxygen saturation 98% on room air. Physical examination confirms neck stiffness and a positive Kernig sign. Lumbar puncture is performed and reveals clear cerebrospinal fluid (CSF) with the following results: - Protein: 120 mg/dL - Glucose: 65 mg/dL (CSF glucose-to-serum glucose ratio 0.6)
- White blood cell count: 200 cells/μL with 90% lymphocytes, 10% neutrophils
- Gram stain: negative
- Bacterial culture: pending
- Blood cultures: negative after 48 hours of incubation The patient denies recent travel, antibiotic exposure, or immunosuppression. She is pregnant (8 weeks gestation). Which organism is most likely responsible for her meningitis?
Answer choices
- ANeisseria meningitidis
- BListeria monocytogenesCorrect answer
- CStreptococcus pneumoniae
- DMycobacterium tuberculosis
- EHaemophilus influenzae type b
- FEnterovirus
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