Asthma USMLE Step 1 Practice Question
A 33-year-old man with newly diagnosed pulmonary tuberculosis (CXR: upper lobe infiltrates) started on rifampin, isoniazid, pyrazinamide, and ethambutol presents with numbness and tingling in his feet. Vital signs: BP 118/76, HR 88, RR 16, Temp 37.2°C, SpO2 98%. He denies visual changes or joint pain. Serum glucose is normal. Which of the following is the best next step to prevent progression of this adverse effect?
Answer choices
- AStart inhaled fluticasone
- BStop rifampin and start azithromycin
- CAdd pyridoxine supplementationCorrect answer
- DSwitch ethambutol to linezolid
- EAdd leucovorin supplementation
- FDiscontinue isoniazid and substitute with moxifloxacin
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