Acute Kidney Injury USMLE Step 1 Practice Question
A 34-year-old woman with systemic lupus erythematosus presents with acute onset hematuria and flank pain. Vital signs: BP 152/96 mmHg, HR 98/min, RR 18/min, Temp 37.2°C, SpO2 98% on room air. Serum creatinine is 2.1 mg/dL (baseline 0.8). Urinalysis reveals 3+ proteinuria, dysmorphic RBCs, and RBC casts. Serum complement levels are low; ANA is positive. Urine eosinophils are absent. Which of the following is the most likely diagnosis?
Answer choices
- AAcute tubular necrosis from drug toxicity
- BAcute interstitial nephritis from NSAID use
- CPrerenal azotemia from volume depletion
- DThrombotic microangiopathy from SLE-associated antiphospholipid syndrome
- ELupus nephritis with acute proliferative glomerulonephritisCorrect answer
- FAcute pyelonephritis with sepsis-induced acute kidney injury
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